Intracoronary ethanol ablation of ventricular premature contractions in patients with preserved left ventricular function

Ventricular premature contractions (VPC) refractory to medical management may require catheter ablation for symptomatic benefit or for compromised ventricular function in the setting of a high VPC burden [1,2]. While most VPCs are amenable to catheter ablation with conventional radiofrequency or cryothermal ablation from an endocardial approach, 8% of VPCs will have an intramural origin [3].Where endocardial and epicardial approaches have failed to eliminate the VPC, intramural sources may require alternative approaches such as intra-coronary ethanol ablation [4]. We present a novel series of three intra-coronary ethanol ablation procedures in two patients with symptomatic VPCs and normal ventricular function.